Job Title Senior Scientist Systems Medicine Global Career Level D Introduction to role Are you ready to dive into the world of Systems Medicine and make a significant impact on drug development As a Senior Scientist you ll be at the forefront of scientific innovation utilizing systems modeling techniques to drive decisions in drug discovery and development Your expertise will be pivotal in developing advanced models that facilitate groundbreaking progress in treating complex diseases Accountabilities Create expand or refine mathematical models to address drug-discovery and development questions Review analyze and prepare available data for modeling purposes and apply best modeling approaches to enhance project decision-making Develop apply PKPD TKTD models to enable translation of findings from preclinical species to humans Develop and utilize mathematical models to enhance quantitative understanding of mechanisms based on literature and in-house data including identifying relevant data for model development optimization and validation Influence experimental design by using available data and appropriate modeling solutions Engage with project teams and present modeling work Contribute to the development and implementation of new modeling and simulation strategies for clinical drug development decisions Stay up-to-date with emerging literature in modeling and simulation sciences Essential Skills Experience PhD or similar degree in pharmacometrics chemical mechanical or biomedical engineering physics applied mathematics or related field Excellent understanding of theory principles and statistical aspects of mathematical modeling and simulation including numerical methods parametrization and ODEs Hand-on knowledge of modeling with ODEs and statistical modelling Experience with modeling and data analysis tools and languages such as R or Matlab or Python Self-directed independent and highly-motivated researcher who excels in a collaborative multi-disciplinary environment Ability to interact across pre-clinical and clinical teams Excellent oral and written communication skills and the ability to interact effectively with scientists in other subject areas with a positive and collaborative attitude Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop models Ability to keep up to date with and propose the implementation of scientific and technological developments Minimum 3 published papers Desirable Skills Experience Industry or postdoctoral experience in building validating and using predictive mathematical models PKPD TKTD mechanistic models Exposure to current principles and concepts in DMPK Toxicology and Safety Experience with PK PKPD TKTD modelling and joint longitudinal modelling tools such as Monolix or any other relevant software s Knowledge of models of biological pathways systems to support translational research Familiarity with the challenges of drug discovery and forward thinking with respect to the general application of mathematical models in discovery and development Evidence of identifying developing and applying innovative solutions to scientific and technological problems faced in systems and predictive modelling Scientific leadership as evidenced by publication record Key Relationships to reach solutions Internal to AZ or team Clinical Pharmacometricians Clinical Pharmacologists Statisticians DMPK M S experts Study project and safety Physicians Translational Scientists Toxicologists External to AZ Credibility with academic partners investigators CROs When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing medicines In-person working gives us the platform we need to connect work at pace and challenge perceptions That s why we work on average a minimum of three days per week from the office But that doesn t mean we re not adaptable We balance the expectation of being in the office while respecting individual flexibility Join us in our unique and ambitious world At AstraZeneca curiosity drives us to explore new scientific frontiers We are committed to making a difference by fusing data and technology with scientific innovation Our inclusive environment encourages collaboration across academia biotech and industry empowering us to tackle some of the world s most complex diseases With a focus on lifelong learning we offer diverse opportunities for career growth while impacting patients lives globally Ready to make an impact Apply now to join our team of innovators

📌 Senior Scientist, Systems Medicine (Karnataka)
🏢 AstraZeneca
📍 Karnataka