Job Description The Senior Scientist leads the design, development, and scale-up of liposomal, nanostructured lipid carrier (NLC), and encapsulated active systems across Flychem's portfolio, including liposomal retinaldehyde/retinol, THD ascorbate, copper tripeptide, recombinant collagen, and multi-molecular-weight hyaluronic complexes. The role owns the path from lab formulation through pilot and production-scale process, delivering robust, reliable, and reproducible carrier systems for labile and difficult-to-deliver actives. It combines hands-on formulation science with process engineering and technology transfer to manufacturing.
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n Key Responsibilities
n n Design and optimise liposomal, NLC, and encapsulated formulations for sensitive actives — retinol, retinaldehyde, tetrahexyldecyl ascorbate, bakuchiol, copper tripeptide, ceramides, azelaic and salicylic acid, arbutin, and enzyme actives — with a focus on stability, encapsulation efficiency, and payload protection.
n Develop and optimise carrier-manufacturing processes: thin-film hydration, ethanol/solvent injection, high-pressure homogenisation, microfluidisation, and extrusion; define and control critical process parameters.
n Select and justify lipid and carrier systems (lecithin, lysolecithin, phospholipids, glucosyl ceramide) and characterise the resulting dispersions.
n Characterise particle size, polydispersity index, and zeta potential by dynamic light scattering; determine encapsulation efficiency and drug loading via ultrafiltration/centrifugation coupled with HPLC/UPLC assay; assess morphology (TEM/cryo-TEM) where required.
n Lead scale-up from bench to pilot to production, ensuring reproducibility and yield; author process development reports, batch manufacturing records, and technology-transfer documentation.
n Design and interpret physical and chemical stability studies (including for oxidation- and light-sensitive actives) and define storage and packaging requirements.
n Partner with QC on analytical method suitability for encapsulated systems,



and with Production/EHS on safe handling of solvents and hazardous inputs during scale-up.
n Provide technical guidance to junior scientists and contribute to project planning and troubleshooting.
n n Required Qualifications
n n M.Sc / M.Pharm / M.Tech in Pharmaceutics, Chemistry, Chemical Engineering, Biotechnology, or a related discipline (Ph.D. in a relevant area is an advantage).
n 4–7 years of experience in formulation and process development, with demonstrable work on liposomes, NLCs/SLNs, or other encapsulation/delivery systems.
n n Required Technical Skills
n n Liposome / lipid-carrier formulation and the associated unit operations (homogenisation, microfluidisation, thin-film hydration, extrusion).
n Colloidal characterisation: DLS (size/PDI), zeta potential, and encapsulation-efficiency determination.
n Working knowledge of HPLC/UPLC for assay of encapsulated actives, ideally in coordination with an analytical team.
n Formulation of labile actives and design of protective/encapsulated systems.
n Scale-up and technology transfer, with sound GMP documentation practice and awareness of cosmetic manufacturing requirements under the Cosmetics Rules, 2020.
n n Preferred / Nice-to-Have
n n Experience in a cosmetic-ingredient, pharmaceutical, or nutraceutical manufacturing environment.
n Familiarity with peptide and protein actives (recombinant collagen, copper tripeptide) or fermentation-derived actives.
n Exposure to Design of Experiments (DoE) / QbD approaches to process optimisation.
n Understanding of regulatory and safety considerations for nano/encapsulated cosmetic ingredients.
n n Soft Skills & Behavioural Competencies
n n Strong problem-solving and a structured, data-driven approach to development.
n Clear technical writing and communication across R&D;, QC, and Production.
n Ability to manage multiple development projects and timelines.
n Mentoring instinct and collaborative working style.
n Ownership and rigour in translating lab work into reproducible manufacturing.
n n How to apply?
n You can apply on LinkedIn or share your CV to .

📌 Senior Scientist -- Liposomal Formulation & Process Development (Hyderabad)
🏢 FlyChem
📍 Hyderabad