Role: Protein Engineering Scientist (AI-Driven Large
Molecule Design)
Location: Science & Technology Park / Venture Center, Pune, Maharashtra
Work Mode: Hybrid/Remote- 6 days
Role Overview

We are looking for a Protein Engineering Scientist with solid hands-on experience in computational protein design and large molecule engineering.

This role focuses on:

● protein and enzyme engineering

● antibody and binder design

● AI-driven structure and sequence generation

● end-to-end large molecule design workflows

You will work at the intersection of biology, AI, and computational modeling to design and optimize next-generation protein therapeutics and engineered biomolecules.

What You’ll Work On

● Designing and optimizing proteins, enzymes, antibodies, and other large molecules for specific functional outcomes

● Working on end-to-end protein engineering workflows from sequence to structure to function

● Applying AI-driven approaches for protein structure prediction and design

● Designing mutations to improve stability, binding affinity, specificity, and activity





● Analyzing protein-protein and protein-ligand interactions

● Integrating generative AI models into protein and enzyme engineering pipelines

● Working with evolving toolchains and adapting to new methods in AI-driven protein design

● Collaborating with cross-functional teams across computational and experimental domains

Key Responsibilities

● Execute protein engineering workflows including sequence design, structure prediction, and optimization

● Work with advanced AI-driven tools such as RFdiffusion, AlphaFold 3, ProteinMPNN, and Boltz-2

● Leverage additional emerging tools and frameworks in protein and large molecule design as required

● Design and evaluate enzyme variants and antibody candidates for therapeutic and industrial applications

● Analyze structural outputs to assess stability, folding, and binding interactions

● Develop and refine computational pipelines for large molecule and pr

📌 Medvolt- Protein Engineer (Pune)
🏢 NextHire
📍 Pune