16 Aug
|
University Of Cambridge
|
Secunderabad
16 Aug
University Of Cambridge
Secunderabad
We are looking for both junior and senior scientists to join our team and contribute to the development of our novel mRNA-based vaccines and therapeutics. The ideal candidates will have experience in nucleic acid delivery systems, particularly focusing on lipid or polymer-based formulations, and will work on advancing our platform for efficient, long-term mRNA stability and delivery. The role will involve formulation discovery, microfluidics, particle size analysis, and nucleic acid quantification in a collaborative, fast-paced workplace.
Key Responsibilities:
- Design, develop, and optimize lipid nanoparticle (LNP) or polymeric formulations for nucleic acid delivery (RNA or DNA), with a focus on mRNA.
- Conduct microfluidics experiments to synthesize, encapsulate, and characterize lipid or polymeric nanoparticles.
- Perform formulation characterization, including particle size and zeta potential measurements, pKa determination, and viscosity assessments.
- Quantify nucleic acids using RiboGreen, NanoDrop spectrophotometry, and other relevant techniques.
- Utilize gel electrophoresis for nucleic acid and protein analysis (including Western blotting).
- Implement and refine nanoparticle purification techniques, such as ultrafiltration and tangential flow filtration (TFF).
- Conduct cell-culture experiments, including transfection of immortalized cell lines with nucleic acids or nucleic acid formulations.
- Set up and conduct high-throughput in vitro screening assays for evaluating formulation effectiveness.
- Support the setup and automation of laboratory protocols, including lab automation equipment setup and programming.
- Participate in animal studies to evaluate drug or vaccine delivery formulations.
- Collaborate with cross-functional teams to troubleshoot and solve technical challenges in formulation and characterization.
- Contribute to the continuous improvement of experimental techniques and methodologies.
Qualifications:
- MSc or PhD in Life Sciences, Ch
📌 RNA Delivery Formulation Discovery and Characterization Scientist (Secunderabad)
🏢 University Of Cambridge
📍 Secunderabad