Experience: 5–9 Years
Function: Downstream Processing / RP Chromatography / Production
Industry: Pharmaceutical / API
Reporting To: Senior Manager / Head – Production

Role Summary

Responsible for execution and supervision of Reverse Phase (RP) chromatography operations in pharmaceutical/API manufacturing, ensuring production targets, product purity, yield, GMP compliance, safety, and timely batch completion.

Key ResponsibilitiesRP Chromatography Operations
Execute and supervise Reverse Phase chromatography purification batches.
Operate and monitor preparative/process-scale chromatography systems.
Optimize and monitor mobile phase, solvent composition, flow rate, loading, gradient, pressure, and other process parameters.
Ensure consistent product purity, recovery, and yield.
Monitor chromatographic profiles and identify abnormalities during processing.

Column Operations
Perform/support column packing, unpacking, cleaning, regeneration, and storage.
Monitor column performance, pressure, resolution, efficiency, and lifetime.




Troubleshoot column-related problems such as channeling, high back pressure, poor resolution, and loss of efficiency.

Production & Batch Execution
Execute manufacturing activities according to approved BMR/BPR, SOPs, and GMP requirements.
Monitor batch progress, yield, recovery, cycle time, and solvent consumption.
Complete manufacturing documentation accurately and on time.
Coordinate with QA, QC, Engineering, Warehouse, and Planning.

Process Troubleshooting
Investigate issues related to:
Low recovery
Poor resolution
Purity failures
High pressure
Peak broadening
Product loss
Column performance
Solvent/mobile-phase issues
Support root-cause investigations and CAPA implementation.

Process Improvement
Improve RP purification yield, purity, throughput, and cycle time.
Reduce solvent consumption and process losses.
Support scale-up and process optimization activities.
Participate in continuous

📌 Senior Manager – Reverse Phase Alimpur
🏢 Pardha Constrcution
📍 Alimpur