Job Description
Job Type - Internship (Can be converted to full-time based on performace)
Job Location - Delhi/Vapi
We are seeking a highly skilled and motivated Structural Biologist to join our drug discovery programs. The ideal candidate will have interest in macromolecular structure determination and modeling, with a knowledge on elucidating protein structures, analyzing ligand binding, and driving rational drug design in collaboration with computational and medicinal chemistry teams.
Key Responsibilities
• Perform structure-based design of small molecules and protein therapeutics.
• Analyze protein-ligand interactions to inform medicinal chemistry and improve lead optimization efforts.
• Conduct molecular dynamics (MD) simulations and free energy calculations to evaluate complex stability and binding energetics.
• Apply structural insights to guide hit-to-lead and lead optimization strategies.
• (Preferred) Utilize machine learning models to support binding site prediction or compound prioritization.
Required Skills & Experience
• Proficient in macromolecular modeling and structure refinement tools (e.g., Phenix, Coot, Chimera, PyMOL).
• Experience with protein-ligand docking, structure validation, and interaction mapping.
• Hands-on experience with molecular dynamics simulations using tools such as GROMACS, AMBER, NAMD, or CHARMM is preferred.
• Familiarity with structure-based drug design platforms (e.g., Schrödinger, AutoDock).
• Scripting or programming experience (Python, R, Bash) for workflow automation and structural data analysis.
Preferred Qualifications:
• MTech/BTech in Structural Biology, Biophysics, Computational Biology or related field.
• Demonstrated knowledge in drug discovery pipelines, especially in target validation and lead optimization.
• Robust Presentation skills, ability to learn new skills
What We Offer
• Work on high-impact, discovery-stage therapeutic programs.
• Collaborative and interdisciplinary research workplace.
• Acc
📌 Structural Biology Intern (India)
🏢 Meril
📍 India