Job Title: Intern – Genetic Biocuration & Systems Biology Interpretation

Location: Rajarajeshwari Nagar, Bengaluru | Onsite

Organization: MetFlux Research Pvt. Ltd.

Employment Type: Internship, with potential conversion to a full-time role based on performance

About Us

MetFlux Research is developing the ΩmeX ecosystem - a connected scientific and computational framework that brings together systems biology, multi-omics data, mechanistic knowledge, and computational modelling to support precision health applications.

Our genetics vertical supports MetSights Precision Genetics, which provides practitioner-oriented genetic risk interpretation, polygenic risk insights, mechanistic variant curation, and personalised health recommendations.

This internship is designed for individuals interested in working at the intersection of human genetics, systems biology, scientific biocuration, and translational interpretation.

Role Overview

As an intern in Genetic Biocuration and Systems Biology Interpretation, you will work with our bioinformatics and systems biology teams to investigate how genetic variants influence genes, pathways, physiological processes, and health-related phenotypes.

This is not primarily a conventional bioinformatics pipeline-development or sequencing-data analysis role. The work is centred on:

- Scientific literature investigation
- Gene and variant biocuration
- Systems-biology interpretation
- Evidence assessment and validation
- Structured scientific documentation
- Translation of genetic findings into biologically meaningful insights

You will help connect individual genetic findings with their wider molecular and physiological context, contributing to the scientific knowledge layers behind MetSights Precision Genetics.

Key Responsibilities

- Conduct structured and in-depth literature research on genes, genetic variants, regulatory mechanisms, biological pathways, and health-related phenotypes.




- Curate and validate variant-level evidence using primary scientific literature and established genomic resources such as ClinVar, dbSNP, GWAS Catalog, Ensembl, OMIM, UniProt, and GTEx.
- Examine how genetic variants may affect gene expression, protein function, molecular pathways, and downstream physiological processes.
- Evaluate the strength, consistency, biological plausibility, and limitations of available evidence.
- Distinguish between direct experimental evidence, population-level associations, computational predictions, and mechanistic hypotheses.
- Develop clear, structured summaries connecting: Variant to gene, Gene to molecular function, Molecular function to pathway, Pathway to physiological process, Physiological process to health-related phenotype.
- Support the scientific review and expansion of polygenic risk score–related knowledge, including biological interpretation of contributing loci and pathways.
- Cross-check curated annotations for scientific accuracy, traceability, consistency, and appropriate interpretation.
- Maintain high-quality biocuration records aligned with MetFlux documentation and evidence standards.
- Use Python or R for organizing datasets, performing quality checks, and supporting small-scale curation automation where useful.
- Contribute to the genetic knowledge and interpretation layers used within the ΩmeX ecosystem and MetSights Precision Genetics.

Who We’re Looking For

Education:

- Graduates or postgraduate students in:
- Human Genetics
- Bioinformatics
- Biotechnology
- Molecular Biology
- Biochemistry
- Computational Biology
- Systems Biology

Or a closely related discipline

Core Competencies:





- Strong foundational understanding of human genetics, gene regulation, molecular biology, and biological pathways.
- Ability to read and critically interpret mechanistic, molecular, and genetic-association studies.
- Familiarity with major genetic and biological databases such as ClinVar, Ensembl, OMIM, GWAS Catalog, UniProt, and GTEx.
- Strong scientific writing and structured summarisation skills.
- Ability to assess evidence critically rather than simply compile information.
- Basic proficiency in Python or R for data organization and quality-control tasks.
- High attention to detail, scientific consistency, and data accuracy.Nice to Have:

Nice to Have

- Interest in precision genomics, polygenic risk scores, systems biology, and personalised health.
- Familiarity with variant interpretation principles and evidence classification.
- Ability to translate complex genetic mechanisms into explicit and scientifically defensible summaries.
- Experience with literature-management tools, notebooks, Git, or basic automation workflows.
- A curiosity-driven and evidence-oriented approach to biological investigation.

Why Join MetFlux

- Receive a competitive internship stipend.
- Gain hands-on experience in a real-world precision genetics program.
- Work with senior scientists across genetics, bioinformatics, and systems biology.
- Develop practical expertise in genetic biocuration, mechanistic reasoning, evidence validation, and scientific writing.
- Learn how genetic findings are connected with pathways, physiological processes, and personalised health interpretation.
- Contribute to the scientific knowledge engine supporting MetSights Precision Genetics.
- High-performing interns may be considered for a full-time role.

To Apply

Send your CV and, optionally, a short note describing your interest in genetic biocuration and systems-biology interpretation to [email protected].

Subject Line: Application – Intern, Genetic Biocuration & Systems Biology

📌 Intern – Genetic Biocuration & Systems Biology Interpretation (Bengaluru)
🏢 MetFlux Research
📍 Bengaluru