Job Purpose

Hands-on experience in R&D;, pilot-scale and plant-scale manufacturing batches, with a robust understanding of organic chemistry, reaction optimization, process development, scale-up, purification, analytical interpretation, and GMP manufacturing practices.

The role involves developing and optimizing chemical processes from laboratory scale through pilot/plant scale, troubleshooting process issues, improving yield and purity, and supporting technology transfer and manufacturing activities.

Key Responsibilities

- Process & Product Development

- Develop, optimize, and establish robust chemical processes for pharmaceutical, API, specialty chemical, and fine chemical products.
- Perform reaction route scouting, process optimization, and laboratory experimentation.
- Optimize critical process parameters such as temperature, time, reagent/solvent quantity, concentration, pH, addition rate, agitation, and reaction conditions.
- Evaluate process efficiency with respect to yield, purity, selectivity, cycle time, solvent consumption, and scalability.
- Identify and troubleshoot process-related issues during development and scale-up.

2. R&D; and Scale-Up Activities:
- Plan and execute laboratory R&D; batches and process optimization experiments.
- Demonstrate successful transition from gram scale to kilogram/pilot scale and plant scale.
- Participate in pilot and commercial manufacturing batches and provide technical support during execution.
- Monitor process performance during scale-up and identify potential scale-dependent issues.
- Support process validation, process improvement, and troubleshooting activities.

3. Purification & Isolation:




- Hands-on experience in various purification and isolation techniques, including: Crystallization / precipitation, Fractional / vacuum distillation, Column chromatography, Impurity purge and control strategies
- The candidate should be able to select and optimize suitable purification technology based on product properties, impurity profile, yield, scalability, and commercial feasibility.

Skills Required
- Familiarity with standard organic reactions and laboratory practices.
- Experience in GMP manufacturing environments, GMP documentation and manufacturing practices.
- Good understanding of purification and basic analytical interpretation.
- Good understanding of HPLC, GC, GC-MS, LC-MS, NMR, IR, UV and melting point data.
- Interpret 1H NMR and 13C NMR spectra for structure confirmation and impurity identification.
- Keen attention to detail and eagerness to learn from senior team members.
- Ability to work in a collaborative team environment and handle multiple lab tasks.
- Basic proficiency in using MS Office for documentation and report preparation
- Follow laboratory SOPs, EHS requirements, and chemical handling procedures
- Adhere to safety guidelines and responsible disposal of chemical waste.

Technical/Functional Proficiency Required
- Proven track record of successful scale-up from lab to pilot/plant.
- Strong problem-solving mindset and ability to work in a fast-paced, project-driven environment.

Educational Qualifications

M.Sc. in Organic / Industrial Chemistry or related field with strong synthetic lab exposure.

Experience Level (If applicable)

3–4 years of experience in chemical R&D; or process development.

📌 Research and Development Executive (Avral)
🏢 Manipal Specialty Chemicals Private
📍 Avral