Position Summary The Research Officer will support the establishment and operation of a novel Yeast Display Platform at Mahape. This platform is being developed to enhance antibody affinity maturation capacity across discovery programs and generate high-quality proprietary data package for AI/ML model generation. The successful candidate will contribute to library construction, yeast strain manipulation, flow cytometry-based screening, molecular biology workflows, and data analysis.

This role offers a unique opportunity to participate in the development of a recent technology platform from the ground up while gaining experience in antibody engineering, lead optimization, and next-generation discovery technologies.

Key Responsibilities

Yeast Display Platform Development

- Support the establishment and optimization of yeast display workflows.
- Execute routine molecular biology and microbiology experiments required for platform development.
- Assist in developing and implementing platform SOPs and best practices.
- Perform routine maintenance of yeast strains, reagents, and laboratory inventories.

Library Construction and Screening

- Conduct cloning, mutagenesis, and library construction activities.
- Perform yeast transformations and monitor library quality and diversity.
- Support affinity maturation campaigns NGS guided affinity maturation campaigns.
- Support sample preparation for Next Gen synthesis.
- Support library preparation workflows for NGS.

Experimental Execution

- Independently perform laboratory experiments following established protocols.
- Maintain accurate experimental records in electronic laboratory notebooks.




- Analyse experimental data and prepare summaries for project discussions.
- Troubleshoot routine experimental challenges under guidance from senior scientists.

Laboratory Operations

- Maintain laboratory equipment and ensure compliance with safety procedures.
- Prepare buffers, media, and reagents required for routine experiments.
- Manage sample tracking and inventory records.

Required Qualifications

Education

- M.Sc. in Biotechnology, Molecular Biology, Microbiology, Biochemistry, Life Sciences, or a related discipline OR
- PhD in Biotechnology, Bioinformatics or any related discipline.

Experience

- 3-6 years of relevant industry or academic research experience.

Required Technical Skills

- Hands-on experience in molecular biology techniques such as:
- PCR
- DNA/RNA isolation
- Gel electrophoresis
- Molecular cloning
- Plasmid preparation
- Experience with NGS library prep workflows such as adapter ligation, indexing/barcoding, Amplicon cleanup using magnetic beads.
- Experience with microbial culture techniques.
- Basic knowledge of protein engineering and antibody discovery concepts.
- Familiarity with experimental data analysis and documentation.

Preferred Skills

- Familiarity with sequencing platforms (Illumina, Thermo Fisher/Ion Torrent, Oxford Nanopore, etc.)
- Exposure to yeast biology or yeast-based expression systems.
- Experience with flow cytometry or FACS.
- Knowledge of antibody display technologies (yeast display, phage display, or related platforms).
- Experience with sequence analysis tools and bioinformatics software.
- Understanding of antibody affinity maturation workflows.

📌 Research Officer (Navi Mumbai)
🏢 IGI
📍 Navi Mumbai