Job Description

Job Description

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Job Purpose:

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Hands-on experience in R&D;, pilot-scale and plant-scale manufacturing batches, with a strong understanding of organic chemistry, reaction optimization, process development, scale-up, purification, analytical interpretation, and GMP manufacturing practices.

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The role involves developing and optimizing chemical processes from laboratory scale through pilot/plant scale, troubleshooting process issues, improving yield and purity, and supporting technology transfer and manufacturing activities.

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Key Responsibilities:

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1. Process & Product Development

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- Develop, optimize, and establish robust chemical processes for pharmaceutical, API, specialty chemical, and fine chemical products.
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- Perform reaction route scouting, process optimization, and laboratory experimentation.
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- Optimize critical process parameters such as temperature, time, reagent/solvent quantity, concentration, pH, addition rate, agitation, and reaction conditions.
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- Evaluate process efficiency with respect to yield, purity, selectivity, cycle time, solvent consumption, and scalability.
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- Identify and troubleshoot process-related issues during development and scale-up.
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2. R&D; and Scale-Up Activities:

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- Plan and execute laboratory R&D; batches and process optimization experiments.
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- Demonstrate successful transition from gram scale to kilogram/pilot scale and plant scale.
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- Participate in pilot and commercial manufacturing batches and provide technical support during execution.
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- Monitor process performance during scale-up and identify potential scale-dependent issues.
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- Support process validation, process improvement, and troubleshooting activities.
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3. Purification & Isolation:





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- Hands-on experience in various purification and isolation techniques, including: Crystallization / precipitation, Fractional / vacuum distillation, Column chromatography, Impurity purge and control strategies
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- The candidate should be able to select and optimize suitable purification technology based on product properties, impurity profile, yield, scalability, and commercial feasibility.
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Skills Required

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- Familiarity with standard organic reactions and laboratory practices.
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- Experience in GMP manufacturing environments, GMP documentation and manufacturing practices.
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- Good understanding of purification and basic analytical interpretation.
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- Good understanding of HPLC, GC, GC-MS, LC-MS, NMR, IR, UV and melting point data.
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- Interpret 1H NMR and 13C NMR spectra for structure confirmation and impurity identification.
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- Keen attention to detail and eagerness to learn from senior team members.
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- Ability to work in a cooperative team environment and handle multiple lab tasks.
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- Basic proficiency in using MS Office for documentation and report preparation
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- Follow laboratory SOPs, EHS requirements, and chemical handling procedures
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- Adhere to safety guidelines and responsible disposal of chemical waste.
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Technical/Functional Proficiency Required

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- Proven track record of successful scale-up from lab to pilot/plant.
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- Strong problem-solving mindset and ability to work in a fast-paced, project-driven environment.
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Educational Qualifications

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M.Sc. in Organic / Industrial Chemistry or related field with strong synthetic lab exposure.

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Experience Level (If applicable)

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3–4 years of experience in chemical R&D; or process development.

📌 Research and Development Executive (Mysuru)
🏢 Manipal Specialty Chemicals Private
📍 Mysuru