Quality Control Analyst – LC-MS/MS

Department

Quality Control / Laboratory Operations

Job Summary

We are looking for a QC Analyst with hands-on experience in LC-MS/MS to perform analytical testing, quality control checks, method validation/verification, instrument maintenance, documentation, and troubleshooting. The candidate will ensure that testing is performed accurately and in accordance with laboratory SOPs, quality standards, and applicable regulatory requirements.

Key Responsibilities

- Perform routine LC-MS/MS analysis of clinical, pharmaceutical, biological, or other laboratory samples as applicable.
- Prepare samples, standards, calibrators, reagents, and controls for analysis.
- Operate and monitor LC-MS/MS instruments and associated software.
- Perform sample extraction techniques such as:
- Protein precipitation
- Liquid-liquid extraction
- Solid-phase extraction (SPE)
- Other applicable sample preparation methods
- Perform calibration, system suitability, QC sample analysis, and batch acceptance.
- Review chromatograms, calibration curves, peak integration, retention time, ion ratios, and other analytical parameters.
- Identify out-of-specification (OOS), out-of-trend (OOT), or abnormal results and support investigations.
- Perform routine instrument troubleshooting and coordinate with engineering/vendor teams when required.
- Support method development, method validation, method verification, and method transfer, as applicable.
- Maintain accurate laboratory records,



worksheets, instrument logs, and analytical reports.
- Follow laboratory SOPs, GLP/GMP/ISO requirements, depending on the organization.
- Ensure proper handling, storage, labeling, and disposal of samples and chemicals.
- Participate in internal audits, external audits, CAPA, deviation investigations, and quality improvement activities.
- Maintain instrument cleanliness and perform routine preventive maintenance.
- Ensure laboratory safety and compliance with chemical and biological handling procedures.

Required Skills

Technical skills:

- LC-MS/MS operation
- HPLC/UPLC fundamentals
- Mass spectrometry principles
- Sample preparation
- Chromatogram interpretation
- Calibration curve preparation
- QC sample analysis
- Method validation/verification
- Troubleshooting
- Documentation and data integrity

Preferred experience:

- Experience with instruments from Sciex, Waters, Thermo Fisher, Agilent, Shimadzu, etc.
- Experience with software such as Analyst, MassLynx, Xcalibur, OpenLab, LabSolutions, or equivalent.
- Knowledge of GLP/GMP/ISO 15189/ISO 17025, depending on the laboratory workplace.

Educational Qualification
- M.Sc./B.Sc. in Chemistry, Biochemistry, Biotechnology, Microbiology, Pharmaceutical Sciences, or a relevant field.
- Experience in analytical testing/clinical laboratory/pharma QC is preferred.

Pay: ₹300,000.00 - ₹800,000.00 per year

Work Location: In person

📌 LCMS Specialist (Hyderabad)
🏢 TEKREANT INDIA
📍 Hyderabad