We are seeking a Senior PBPK Modeler to join our growing Modeling & Simulation team to support in silico projects across oral, modified-release, and complex drug products.

This is a hands-on scientific role focused on regulatory-grade model development, working closely with modelers and project leads to deliver high-impact in-silico evidence for drug development and regulatory decision-making.

You will play a critical role in scaling our PBPK capability and supporting multiple concurrent programs as project demand continues to grow.

Key Responsibilities

PBPK Modeling & Simulation
• Hands on expereince in Develop, calibrate, and validate PBPK models for small molecules and metabolites using PK-Sim / MoBi (preferred) or equivalent platforms
• Support oral IR, MR/ER, and complex formulations, including metabolite kinetics and accumulation risk
• Perform scenario simulations (dose, formulation, population, DDIs, food effect, steady-state exposure)
• Integrate in vitro data (solubility, permeability, dissolution, enzyme kinetics) into mechanistic models

IVIVR / IVIVC Support




• Contribute to IVIVR and IVIVC strategies linking dissolution, absorption, and systemic exposure
• Support formulation design space exploration using PBPK-led approaches
• Assist in virtual screening of formulation or release profiles where applicable

Regulatory & Scientific Deliverables
• Generate regulatory-quality reports, model descriptions, and justification documents
• Support MIDD-aligned submissions, briefing documents, and scientific responses
• Ensure modeling work meets internal quality, traceability, and documentation standards

Cross-Functional Collaboration
• Work closely with senior PBPK modelers, formulation scientists, and project managers
• Support internal knowledge transfer and scientific discussions
• Assist in mentoring junior team members as the group scales

Required Qualifications
• Advanced degree (MS / PhD) in Pharmaceutics, Pharmacokinetics, Pharmaceutical Sciences,

📌 Senior Scientist (Hyderabad)
🏢 InSilicoMinds
📍 Hyderabad