We are seeking a Senior PBPK Modeler to join our growing Modeling & Simulation team to support in silico projects across oral, modified-release, and complex drug products.

This is a hands-on scientific role focused on regulatory-grade model development, working closely with modelers and project leads to deliver high-impact in-silico evidence for drug development and regulatory decision-making.

You will play a critical role in scaling our PBPK capability and supporting multiple concurrent programs as project demand continues to grow.

Key Responsibilities

PBPK Modeling & Simulation

- Hands on expereince in Develop, calibrate, and validate PBPK models for small molecules and metabolites using PK-Sim / MoBi (preferred) or equivalent platforms
- Support oral IR, MR/ER, and complex formulations, including metabolite kinetics and accumulation risk
- Perform scenario simulations (dose, formulation, population, DDIs, food effect, steady-state exposure)
- Integrate in vitro data (solubility, permeability, dissolution, enzyme kinetics) into mechanistic models

IVIVR / IVIVC Support

- Contribute to IVIVR and IVIVC strategies linking dissolution, absorption, and systemic exposure
- Support formulation design space exploration using PBPK-led approaches
- Assist in virtual screening of formulation or release profiles where applicable

Regulatory & Scientific Deliverables
- Generate regulatory-quality reports, model descriptions, and justification documents
- Support MIDD-aligned submissions, briefing documents, and scientific responses
- Ensure modeling work meets internal quality, traceability, and documentation standards

Cross-Functional Collaboration
- Work closely with senior PBPK modelers,



formulation scientists, and project managers
- Support internal knowledge transfer and scientific discussions
- Assist in mentoring junior team members as the group scales

Required Qualifications

- Advanced degree (MS / PhD) in Pharmaceutics, Pharmacokinetics, Pharmaceutical Sciences, Chemical Engineering, or related field
- Robust hands-on experience with PBPK modeling
- Practical experience using PK-Sim / MoBi (strongly preferred) or equivalent PBPK platforms
- Solid understanding of ADME, biopharmaceutics, and clinical pharmacokinetics
- Experience integrating in vitro, preclinical, and clinical data into mechanistic models
- Ability to independently execute modeling tasks with minimal supervision

Preferred / Nice-to-Have
- Experience with modified-release / extended-release formulations
- Exposure to IVIVC / IVIVR development
- Familiarity with regulatory expectations (FDA / EMA) for PBPK and MIDD
- Experience supporting regulatory submissions or scientific advice meetings
- Programming/scripting exposure (R, MATLAB, Python) is a plus but not mandatory

What We’re Looking For

- Strong scientific reasoning and problem-solving skills
- Comfortable working in a fast-growing, multi-project environment
- Detail-oriented with a focus on scientific rigor and regulatory defensibility
- Collaborative mindset and willingness to support team growth

Why Join Us

- Work on high-impact PBPK and IVIVR/IVIVC programs across diverse drug products
- Exposure to regulatory-grade, real-world modeling challenges
- Opportunity to grow into technical leadership as the team scales
- Be part of a team where in-silico modeling directly drives development and regulatory decisions

📌 Senior Scientist - Modeling & Simulation (Hyderabad)
🏢 InSilicoMinds
📍 Hyderabad