ADME Scientist, ADME/IVB Profiling team

(ADME - Absorption, Distribution, Metabolism, and Excretion)

(IVB - In Vitro Bioanalysis, often referred to as in vitro DMPK (Drug Metabolism and Pharmacokinetics)

About the role

We are seeking a ADME scientist to growth our compound Profiling team (full time role). Specialised in DMPK of small molecule therapeutics, the ideal candidate will have a proven track record in developing ADME methods, profiling compounds in ADME assays and executing PK studies supporting drug projects at Discovery & PreClinical stage.

As a key member of Topia Profiling team, you will drive data quality & efficiency for Program execution. You will leverage your experience & expertise in wet lab activities as well as keeping ELN records up to date.

This role is part of Topia own capabilities in delivering drug pipeline of internal and partnered projects while having an impact on expanding Topia Tech Infrastructure.

This Ahmedabad-based position reports directly to ADME/IVB Profiling Senior Manager.

Key Responsibilities

Experimental Design & Execution

- Conduct in vitro ADME assays and in vivo DMPK studies, including aqueous solubility (UV/HPLC/LCMS), permeability, metabolic stability, protein binding, CYP inhibition, and CYP profiling.
- Develop and validate analytical methods (LC-MS/MS, HPLC) for drug quantification.
- Perform pharmacokinetic and bioanalytical studies to characterize drug disposition.

Data Analysis & Interpretation

- Perform data processing, statistical analysis, and interpretation of ADME and PK results.
- Provide scientific recommendations for candidate selection and dose regimen design.

Collaboration & Reporting





- Coordinate effectively with cross-functional teams (e.g., chemistry, biology, clinical).
- Prepare clear, well-documented reports and presentations for internal and external stakeholders.
- Act as Topia Scientific Excellences ambassador, promoting our culture of collaboration and inclusion.

Qualifications & Skills

- PhD or Masters in Pharmacology, Pharmaceutical Sciences, Biochemistry, or related field.
- 3–5 years for entry-level; 7+ years for senior/principal scientist roles.
- Strong knowledge of drug metabolism pathways, ADME assay validation, optimization, and enzyme kinetics.
- Experience in running PK studies (in life and/or analytical phase) is a plus
- Proficiency with bioanalytical techniques (multimode readers, LC-MS/MS, HPLC).
- Familiarity with data analysis software and statistical tools.
- Understanding of regulatory guidelines (FDA, EMA) for bioanalytical method validation.
- Excellent communication, problem-solving, and collaboration skills.
- Excellent communicator (English) with the ability to work collaboratively in a team-oriented global setting; strong analytical skills, record-keeping orientated and result-driven mindset
- Enthusiastic about external partnerships and customer-facing behaviour

What we offer

- Competitive salary, including benefits
- Flexible working hours
- Opportunity to contribute to groundbreaking AI innovations in Healthcare and strategic influence over the expansion of an AI-native TechBio organisation spearheading Precision Design of new drugs
- Collaborative culture with access to a global network of experts
- Professional development and involvement in high impact projects.

📌 ADME Chemist (Ahmedabad)
🏢 Topia Life Sciences
📍 Ahmedabad