Job Description
• We are seeking a highly skilled and motivated Structural Biologist to join our drug discovery programs. The ideal candidate will bring deep expertise in macromolecular structure determination and modeling, with a focus on elucidating protein structures, analyzing ligand binding, and driving rational drug design in collaboration with computational and medicinal chemistry teams.
Key Responsibilities
• Analyze protein-ligand interactions to inform medicinal chemistry and lead optimization efforts.
• Conduct molecular dynamics (MD) simulations and free energy calculations to evaluate complex stability and binding energetics.
• Apply structural insights to guide hit-to-lead and lead optimization strategies.
• (Preferred) Utilize machine learning models to support binding site prediction or compound prioritization. Required Skills &
Experience:
• Strong expertise in structural biology techniques, such as crystallography, cryo
- EM, or NMR are desirable.
• Proficient in macromolecular modeling and structure refinement tools (e.g., Phenix, Coot, Chimera, PyMOL).
• Experience with protein-ligand docking, structure validation,
and interaction mapping.
• Hands-on experience with molecular dynamics simulations using tools such as GROMACS, AMBER, NAMD, or CHARMM.
• Familiarity with structure-based drug design platforms (e.g., Schrödinger, AutoDock).
• Scripting or programming experience (Python, R, Bash) for workflow automation and structural data analysis. Preferred
Qualifications:
• Ph.
D. in Structural Biology, Biophysics, Computational Biology or related field.
• Demonstrated experience in drug discovery pipelines, especially in target validation and lead optimization.
• (Preferred) Background in machine learning or AI applied to biomolecular structure or ligand interaction prediction.
• Solid publication record or demonstrated project impact in therapeutic development.
What We Offer
• Work on high-impact, discovery-stage therapeutic programs.
• Collaborative and interdisciplinary research environment.
• Access to state-of-the-art computational and structural biology platforms.
📌 Structural Biologist (Vapi)
🏢 Meril
📍 Vapi