- however,it leads to only 30-50% achieving low disease activity and most patients require addition of other DMARDs (conventional,biologic or targeted-synthetic)
- Preferred Qualifications: Graduate . Age Limit: 28 Years .
- Preferred Language: English,Kannada,Tamil,Telugu
Job Summary
Bangalore
Rheumatoid Arthritis affects approximately 0.5-1% of the adult population, translating into a substantial disease burden and contributing disproportionately to societal disability. Methotrexate monotherapy is the standard first-line treatment; however, it leads to only 30-50% achieving low disease activity and most patients require addition of other DMARDs (conventional, biologic or targeted-synthetic). Initiating treatment with combination of methotrexate and hydroxychloroquine, may improve efficacy by 10-20%; partly by increasing methotrexate levels.
In addition, hydroxychloroquine has favorable metabolic effects like lipid lowering. Despite widespread use, robust adequately powered randomized evidence comparing first-line methotrexate monotherapy with methotrexate-hydroxychloroquine combination is lacking.
This proposed study is a Sequential step-up strategy trial that mirrors real-world decision making and aims to answer two clinically relevant questions in one study with a resource-effective framework: (i) the optimal initial csDMARD strategy, and (ii) the most effective step-up approach in patients with inadequate response.
By generating pragmatic and contextually relevant evidence, this study has the potential to directly inform treatment algorithms in resource-constrained settings.
No of Vacancy: One
Key Responsibilities
- Conduct detailed screening and recruitment of study -participants
- Study Implementation Coordination
- Data Management Quality Control
- Sample Collection Handling
- Maintain study logs
- Participant Counselling Retention
Eligibility Criteria
- Preferred Qualifications: Graduate
- Age Limit: 28 Years
- Preferred Language: English, Kannada, Tamil, Telugu
Disclaimer: This job posting has been aggregated from external source. Role details, content, and availability are subject to change. Applicants are advised to confirm the latest information directly on the company website before applying.
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