for Process/Kilo Lab chemists

- Design, develop, and optimize robust, safe, cost-effective, and environmentally friendly synthetic routes for Target molecules and chiral intermediates.
- Evaluate reaction parameters (temperature, stoichiometry, addition rate, order of addition, work-up, and crystallization) to improve yield, purity, and operational cycle times.
- Perform impurity profiling, isolation, and characterization of process-related impurities and degradation products.

Translate bench-scale (gram-level) procedures to Kilo-Lab scale (multi-gram to kilogram batches). Operate glass-lined reactors, hydrogenation units, rotary evaporators, and filtration assemblies in the Kilo-Lab environment.

¢ Support or lead technical transfer of processes from the laboratory to pilot plant or commercial manufacturing sites.

¢ Monitor critical process parameters (CPPs) and record batch data accurately in Electronic Lab Notebooks (ELNs) and batch production records





¢ Perform or coordinate in-process analytical testing using techniques such as HPLC, GC, NMR, TLC, LC-MS, and Karl Fischer (KF).

¢ Troubleshoot chemical reactions, equipment malfunctions, or yield drops during scale-up runs.

¢ Collaborate closely with Analytical Research and Development (AR&D;) and Quality Control (QC) teams.

Required Qualifications & Skills

¢ Education: M.Sc. in Organic Chemistry

Experience:

¢ 2 8 years of hands-on experience in synthetic organic chemistry, process R&D;, or Kilo-Lab/pilot plant operations.

Technical Skills:

¢ Robust foundation in multi-step organic synthesis and reaction mechanisms.

¢ Proven experience in scale-up from bench scale to multi-kilogram Kilo-Lab batches.

¢ Familiarity with safety assessments

¢ Proficiency with analytical tools (NMR, HPLC, GC, LCMS) to interpret data independently

📌 Research Associate-IV (Hyderabad)
🏢 Apitoria Pharma
📍 Hyderabad