Note: This is a Forecasted Opportunity.

General Information Document Type: Grants Notice Opportunity Number: RFA-CA-25-033 Opportunity Title: Glioblastoma Therapeutics Network (GTN; U19 Clinical Trial Required) Opportunity Category: Discretionary Opportunity Category Explanation: Funding Instrument Type: Cooperative Agreement Category of Funding Activity: Health Category Explanation: Expected Number of Awards: Assistance Listings: 93.394 -- Cancer Detection and Diagnosis Research 93.395 -- Cancer Treatment Research Cost Sharing or Matching Requirement: No Version: Forecast 1 Forecasted Date: Sep 17, 2025 Last Updated Date: Sep 17, 2025 Estimated Post Date: Nov 28, 2025 Estimated Application Due Date: May 27, 2026 Estimated Award Date: Mar 05, 2027 Estimated Project Start Date: Mar 05, 2027 Fiscal Year: 2027 Archive Date: Estimated Total Program Funding: Award Ceiling: Award Floor: Eligibility Eligible Applicants: Small businesses Others (see text field entitled "Additional Information on Eligibility" for clarification) County governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments)



Public and State controlled institutions of higher education Independent school districts Private institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments City or township governments Additional Information on Eligibility: Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations; Additional Information Agency Name: National Institutes of Health Description: Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically.

Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms. To implement this concept, a highly team-oriented GBM Therapeutics Network (GTN) of cross-cutting teams will be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through IND studies, into pilot clinical studies in humans.

Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process.

Link to Additional Information: Grantor Contact Information: Suzanne Forry, Ph.D. (phone hidden) National Cancer Institute (NCI)

📌 Glioblastoma Therapeutics Network (GTN;Clinical Trial Required) (Bathinda)
🏢 The Warfighter Research Foundation
📍 Bathinda