General Information Document Type: Grants Notice Funding Opportunity Number: PAR-25-450 Funding Opportunity Title: Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed) Opportunity Category: Discretionary Opportunity Category Explanation: Funding Instrument Type: Grant Category of Funding Activity: Health Income Security and Social Services Category Explanation: Expected Number of Awards: Assistance Listings: 93.350 -- National Center for Advancing Translational Sciences 93.865 -- Child Health and Human Development Extramural Research Cost Sharing or Matching Requirement: No Version: Synopsis 1 Posted Date: Sep 22, 2025 Last Updated Date: Sep 23, 2025 Original Closing Date for Applications: Jul 20, 2028 Current Closing Date for Applications: Jul 20, 2028 Archive Date: Aug 25, 2028 Estimated Total Program Funding: Award Ceiling: $ Award Floor: $ Eligibility Eligible Applicants: County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled "Additional Information on Eligibility" for clarification) Public housing authorities/Indian housing authorities Special district governments Private institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts Small businesses Native American tribal governments (Federally recognized) City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Additional Information on Eligibility: Other Eligible Applicants include the following:



Alaska Native and Native Hawaiian Serving Institutions

• Asian American Native American Pacific Islander Serving Institutions (AANAPISISs)

• Eligible Agencies of the Federal Government

• Faith-based or Community-based Organizations

• Hispanic-serving Institutions

• Historically Black Colleges and Universities (HBCUs)

• Indian/Native American Tribal Governments (Other than Federally Recognized)

• Regional Organizations

• Tribally Controlled Colleges and Universities (TCCUs)

• U.S. Territory or Possession

• Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information Agency Name: National Institutes of Health Description: This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of clinical projects that address critical needs for clinical trial readiness in rare diseases. The initiative seeks applications that are intended to facilitate rare diseases research by enabling productive and effective movement of candidate therapeutics or diagnostics toward clinical trials, and to increase their likelihood of success. This could be through the development and testing of rigorous biomarkers and clinical outcome assessment measures, or by defining the presentation and course of a rare disease to enable the design of upcoming clinical trials.

Link to Additional Information: https://grants.nih.gov/grants/guide/pa-files/PAR-25-450.html Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact: NIH Grants Information [email protected] See Section VII.

Agency

Contacts within the full opportunity announcement for all other inquires.

📌 Clinical Trial Readiness for Rare Diseases, Disorders, and SyndromesClinical Trial Not Allowed) (Bathinda)
🏢 The Warfighter Research Foundation
📍 Bathinda