Position Title: ARD Characterization Leader NMR Expert
Function: Analytical Research and Development / Molecular Characterization
Location: Hyderabad, Telangana
Reporting To: Head of Analytical R&D; / Characterization Sciences

Role Summary

The ARD Characterization Leader NMR Expert will provide scientific and technical leadership for nuclear magnetic resonance spectroscopy-based characterization across a diverse portfolio, including small molecules, peptides, antibody-drug conjugates, oligonucleotides, linkers, impurities, intermediates, and related complex modalities. The role is responsible for designing, executing, interpreting, and reviewing advanced one-dimensional and two-dimensional NMR experiments to support structure elucidation, identity confirmation, impurity characterization, quantitative analysis, method development, regulatory submissions, and project decision-making.

Key Responsibilities
- Lead NMR characterization strategies for small molecules, peptides, ADC payloads, linkers, oligonucleotides, impurities, degradation products, intermediates,



and reference standards.
- Design and execute fit-for-purpose NMR experiments including 1D proton, carbon, phosphorus, fluorine, and other relevant nuclei based on molecule class and project need.
- Apply advanced 2D NMR techniques such as COSY, TOCSY, HSQC, HMBC, NOESY, ROESY, DOSY, J-resolved, HSQC-TOCSY, and selective experiments for structural assignment and connectivity confirmation.
- Interpret complex NMR datasets to support stereochemical assignment, sequence confirmation, conformational analysis, site-specific modification assessment, impurity identification, and structure confirmation.
- Develop, optimize, qualify, and validate NMR methods, including quantitative NMR approaches, in alignment with scientific, quality, and regulatory expectations.
- Provide expert review of NMR reports, analytical data packages, method documents, investigation summaries, and regulatory-supporting characterization docu

📌 AR&D Characterization Leader (Hyderabad)
🏢 Sai Life Sciences
📍 Hyderabad