Research Associate Single cell and nuclear Transcriptomics

Research Overview: Parkinson's disease is a clinically and biologically heterogeneous neurodegenerative disorder. It is the second most common neurodegenerative disease globally and represents one of the fastest growing neurological disorders in terms of prevalence and disability burden. Emerging evidence suggests that somatic genomic variation and clonal evolution in the brain may contribute to neuronal and synaptic vulnerability. Building on previous work involving whole-genome sequencing and detection of low-frequency somatic variants, this project aims to systematically characterise the genetic landscape and clonal architecture of brain cells in PD in the Indian population using post-mortem brain tissue. In addition, the project also aims to investigate the heterogeneity of blood and brain cell populations using PBMCs and induced pluripotent stem cell (iPSC)-derived brain organoids from PD patients and healthy controls through Single Cell Transcriptomics.



We are looking out for a motivated and skilled Research Associate to join an interdisciplinary research project focused on understanding the molecular and cellular mechanisms underlying Parkinson's disease (PD). The project integrates genomics, single-cell and single-nucleus transcriptomics, stem cell biology, and bioinformatics approaches to investigate somatic genomic variation, clonal evolution, and cellular heterogeneity to better understand the cellular and molecular basis of PD in Indian population. The specialized skills we are seeking in candidates include expertise in single-cell/nucleus sequencing, flow cytometry, single cell sorting, and molecular biology techniques.

1. Key Responsibilities

Experimental and Technical Responsibilities
- Isolation of nuclei from in vitro cultured cells and fresh frozen post-mortem brain tissue
- Flow Cytometry and Sorting proficient in handling flow cytometers such as BD Fortessa and Sorters such as BD FACSA

📌 Research Associate Single cell and nuclear Transcriptomics (Bengaluru)
🏢 SKAN Research Trust
📍 Bengaluru