Position Title: Instrument Chemist / Senior Analyst / Executive – Instrumentation

Job Overview:

An Instrument Chemist with 2 to 3 years of experience specializes in the routine operation, basic calibration, and troubleshooting of high-end analytical equipment. This role typically operates within Quality Control (QC), Analytical Research and Development (AR&D;), or commercial testing laboratories (Pharma, Food, Environmental, Agrochemical).

- Experience Required: 2 to 3 years of hands-on laboratory experience

· Salary: Up to 3.6 LPA

- Location: Head Office, Sindhubhavan Ahmedabad
- Core Focus: Advanced chromatographic and mass spectrometric analysis (GC, GC-MS, GC-MS/MS, HPLC)
- Education: Master’s Degree in Chemistry, Analytical Chemistry, or Pharmaceutical Sciences

Key Responsibilities 1. Instrument Operation & Testing

- Execute sample analysis using Gas Chromatography (GC) and High-Performance Liquid Chromatography (HPLC).
- Perform trace-level quantification using hyphenated techniques like GC-MS and GC-MS/MS for residual solvents, pesticides, or impurities.
- Prepare samples using techniques like liquid-liquid extraction, Solid-Phase Extraction (SPE), and headspace sampling.

2. Calibration & Maintenance

- Conduct routine calibration of HPLC and GC systems to ensure instrument compliance.
- Perform basic maintenance, including replacing GC septa, liners, syringe needles, HPLC columns, guard columns, and mobile phase filters.
- Execute system suitability tests (SST) prior to sample batch execution to verify instrument performance. [1, 2, 3, 4]

3. Data Analysis & Documentation

- Process raw chromatographic data using software like Empower, Chromeleon, or LabSolutions.
- Review peak integrations,



interpret mass spectra fragments, and calculate final concentrations against standards.
- Maintain meticulous documentation of raw data, logbooks, and analyst worksheets in line with Valuable Laboratory Practices (GLP).

4. Compliance & Troubleshooting

- Investigate Out of Specification (OOS) or Out of Trend (OOT) results under senior supervision.
- Identify system errors like baseline drift, pressure fluctuations, or ghost peaks, and implement initial corrective actions.
- Adhere to safety, data integrity, and regulatory protocols (such as USFDA, MHRA, or NABL/ISO 17025 depending on the industry).

Required Technical Skills

- HPLC/GC: Proficiency in standard isocratic and gradient runs, injection mechanisms, and standard detectors (UV-Vis, PDA, FID, ECD).
- Mass Spectrometry: Understanding of electron ionization (EI), single quad (MS) scanning, and triple quadrupole (MS/MS) Multiple Reaction Monitoring (MRM) modes.
- Software: Experience with chromatography data systems (CDS) and basic mass spec tuning interfaces.
- Method Verification: Competence in assisting senior scientists with method validation and verification protocols.

Soft Skills & Behavioural Competencies

- Strong attention to detail
- Analytical thinking and problem-solving
- Clear communication for cross-functional collaboration
- Time management to handle high sample throughputs

Pay: ₹300,000.00 - ₹360,000.00 per year

Application Question(s)

- Do you have Master’s Degree in Chemistry, Analytical Chemistry, or Pharmaceutical Sciences?
- Do you have hands-on laboratory experience?
- Do you have experience in Advanced chromatographic and mass spectrometric analysis (GC, GC-MS, GC-MS/MS, HPLC)

Work Location: In person

📌 Instrument Chemist / Senior Analyst / Executive – Instrumentation (Ahmedabad)
🏢 Client Of Talentkhoj Hr Solutions
📍 Ahmedabad