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LC-MS/MS Operator

1. Position Details

Job Title: LC-MS/MS Operator / AnalystDepartment: Quality Control Reports To: QC Manager Industry: Food Testing / Honey Testing / FMCG

2. Job Purpose To operate, maintain, and troubleshoot the LC-MS/MS system and perform accurate analytical testing of samples in accordance with approved methods, SOPs, quality standards, and laboratory requirements.

3. Key Responsibilities

LC-MS/MS Operation

- Operate and monitor LC-MS/MS instruments as per approved SOPs and test methods.
- Perform instrument start-up, shutdown, tuning, calibration, and performance verification.
- Prepare mobile phases, standards, reagents, and samples.
- Carry out sample extraction, cleanup, dilution, and final preparation.
- Create and manage analytical sequences and sample batches.
- Monitor chromatograms, retention time, peak shape, ion ratios, and system suitability.

Method & Analytical Work

- Perform analysis for residues and contaminants such as:
- Antibiotics
- Pesticides
- Veterinary drug residues
- Adultration(SMR,TMR)
- Other chemical contaminants, as applicable
- Review analytical data and identify abnormal or out-of-specification results.
- Perform repeat analysis, investigation, and troubleshooting where required.

Quality & Documentation

- Maintain complete and accurate raw data, worksheets, logbooks, and analytical records.
- Follow GLP, GMP, ISO/IEC 17025, and applicable laboratory quality requirements.
- Ensure proper documentation of instrument calibration, maintenance, and breakdown records.
- Participate in method validation, verification, recovery studies, precision studies, and measurement uncertainty activities.
- Support internal audits, external audits, and regulatory inspections.

Instrument Maintenance





- Perform routine preventive maintenance of LC-MS/MS and associated equipment.
- Check pumps, autosampler, columns, source cleanliness, gas supply, and vacuum performance.
- Coordinate with service engineers for major maintenance and breakdowns.
- Maintain inventory of columns, solvents, standards, consumables, and spare parts.

4. Educational Qualification B.Sc. / M.Sc. in Chemistry, Analytical Chemistry, Biotechnology, Food Technology.

5. Experience

- 2–5 years: LC-MS/MS Operator / Analyst
- Experience in an NABL-accredited laboratory will be preferred.
- Experience in food, honey, pharmaceutical, environmental, or residue testing is an advantage.

6. Required Technical Skills

- Hands-on knowledge of LC-MS/MS operation.
- Knowledge of HPLC/UHPLC systems.
- Understanding of MRM/SRM transitions.
- Knowledge of chromatographic integration and data processing.
- Experience with calibration curves and quantification.
- Knowledge of sample preparation techniques such as QuEChERS, SPE, and LLE.
- Understanding of method validation and verification.
- Knowledge of system suitability and QC sample requirements.
- Familiarity with laboratory software and instrument data systems.

7. Desired Personal Skills

- Attention to detail and accuracy.
- Good documentation practices.
- Analytical and troubleshooting skills.
- Ability to work independently and in a team.
- Positive communication and reporting skills.
- Ability to handle multiple samples and meet testing timelines.

8. Key Performance Indicators (KPI)

- Number of samples analyzed within TAT.
- Accuracy and quality of analytical results.
- Instrument uptime and performance.
- Compliance with SOPs and quality requirements.
- Timely completion of documentation.
- Reduction in repeat analysis and analytical errors.

Benefits:
- Food provided

📌 LCMS/MS (Baghpat)
🏢 AMBROSIA NATURAL PRODUCTS (INDIA) PRIVATE
📍 Baghpat